In addition, people in both groups burned calories faster when their weight was higher than normal. They found that both groups reduced their energy expenditure when their weight was lower than normal, slowing their metabolism, and leading to both physiological and psychological signs of semi-starvation. The study involved 18 obese men and women and 23 people who had never been obese. Hirsch and his colleagues Rudolph Leibel and Michael Rosenbaum gave patients precisely defined formula diets to make them gain or lose ten percent of their body mass, and carefully monitored their food intake, energy expenditure, and weight changes. The work was based on more than ten years of clinical research at the Rockefeller University Hospital.
The study was quickly cited as a classic in the field for its exploration of the regulation of human body weight. During that time, in 1995, he published what was perhaps his most widely known study, which offered an explanation for why people who lose weight tend to regain it over time. Hirsch was physician-in-chief of the hospital from 1992 to 1996. These advances allowed Hirsch and colleagues to study how people’s diets affect their blood concentration of different types of fats-observations that contributed to a growing understanding of the relationship between diet and heart disease. Ahrens, Jr., to pioneer techniques for separating and studying fats in blood and adipose tissue, as well as new methods for more easily obtaining patient research samples. Over the next decades, Hirsch’s research helped to alter this view by highlighting the dynamic interactions among diet, metabolism, and obesity.Įarly in his career at Rockefeller, Hirsch worked with Edward H. In the late 1950s, when he became interested in studying obesity, most scientists considered fat, or adipose tissue, to be biologically inert-a passive insulator in which the body stores energy in the form of triglycerides. Hirsch joined Rockefeller’s faculty in 1954 and remained there for the rest of his career.
“Jules Hirsch was a brilliant clinical investigator whose meticulous studies led to his landmark discovery that the body responds to weight loss by reducing energy expenditure, providing a crucial new insight into why obese individuals have so much difficulty losing weight and sustaining the weight loss,” says Barry Coller, vice president for medical affairs and the current physician-in-chief of The Rockefeller University Hospital.
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